Studies on the synthesis of gimeracil


کتابخانه الکترونیکی دیتا ساینس

شناسه: Article-1612217

عنوان: Studies on the synthesis of gimeracil


قیمت: رایگان

لینک دانلود مستقیم:

Objective To synthesize gimeracil,which is a potent dihydropyrimidine dehydrogenase inhibitor.Methods Gimeracil was synthesized by four steps from malononitrile,trimethyl orthoacetate and 1,1-dimethoxy-trimethylamine via condensation,cyclization,chlorination and hydrolysis reactions.Results Gimeracil was synthesized in overall yield of 65.6%,its structure was confirmed by MS,()~1H-NMR as well as elemental analysis.Intermediate compounds were confirmed by MS and()~1H-NMR.Conclusions The improved process has advantages of lower cost,mild reaction conditions,convenient work-up.It is suitable for industrial production.


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